The attack at a popular shrine of a Sufi Saint, Sakhi Sarwar, in Dera Ghazi Khan, a remote district in the province of established Punjab, said police officials. An annual festival was the shrine connection underway as hundreds of worshippers pushed if the attackers blew up their explosives.
Police said that the attackers could be obtained not because of the strict security measures within the shrine.
With some of the wounded in critical condition, rescue officials said, was the number of casualties expected to increase.
A third attacker, he was seriously wounded, was arrested after his jacket explosives laden could not completely to the detonation. The man appeared from the tribal regions along the Afghan border, said police.
The injured were taken to a hospital. Emergency workers said that they faced difficulties in rescue saw.
Tehreek-e-Taliban Pakistan or movement of the Taliban, an umbrella organization of militant, responsibility for the attack claimed, Reuters reported.
Taliban fighters have attacks on Sufi shrines to around the country, together with Government targets and security force installations.
The attack on Sunday was considered another attempt by militant, strengthen the ideological divide, which exist in different schools of Sunni Islam.
Deobandis are a puritanical branch of Sunni Islam, which belong to most of the country's militant groups. Followers of the Barelvi sect, on the other hand believe in mysticism, venerate Saints and shrines, and considered to be tolerant and accommodating others.
If no accurate statistics are available, is estimated that more than 75% of the population of Pakistan keeps to the Barelvi School of thought, following many Sufi practices. Punjab, wealthy and populated province in the country, has a Barelvi majority. Hard-line Deobandis view Barelvis heretics.
Barelvi religious leaders described the attacks as an attempt to sow sectarian fighting.
"This is an act of terrorism by the Taliban," said Sahibzada Muhammad Fazal Kareem, a member of the European Parliament and head of the Sunni Ittihad Council, an Alliance of eight religious parties against the Taliban.
Mr Kareem said "Taliban want the peace of the country, and attacks on shrines destroy a heinous conspiracy, sectarian tensions and riots spark".
He criticized the Government for this, that adequate security on shrines.
The shrine of Sakhi Sarwar, Holy century is 25 km from the city in the southern part of the province of Punjab. Militant threats against the shrine exhibition had, said police officials.
Dera Ghazi Khan is bounded on the North-Western Khyber Pakhtunkhwa province and the province of Balochistan and is known as the gateway to the Punjab.
Recently, concerns were raised that, from the tribal regions of the province of Khyber Pakhtunkhwa, formerly North-West Frontier Province, militant, Dera Ghazi Khan have used as a route, enter to Punjab.
Concerns about the increasing militancy and extremism have also in recent years in the southern province of Punjab, appeared with feudal influence is still powerful and most of the population impoverished and uneducated. The region also teems with madrasas or religious seminars.
Prime Minister Yousaf Raza GILANI condemned the attack.
"Such cowardly terrorist acts make it clear that the guilty involved all believe nor believe all people have values,", said a statement by the Prime Minister's Office.
Salman Masood reported from Islamabad and Waqar GILLANI from Lahore, Pakistan.
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